Yoram Vodovotz, PhD



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412-648-3758
Fax: 412-383-5946

W944 Biomedical Sciences Tower

200 Lothrop St.

Pittsburgh, PA 15213

Professor of Surgery

Education

PhD (Immunology) Cornell University Graduate School of Medical Sciences

BS (Biochemistry) University of Wisconsin-Madison

Research Summary

Yoram Vodovotz, Ph.D., is a Professor of Surgery, Immunology, Computational and Systems Biology, Bioengineering, Clinical and Translational Science, and Communication Science and Disorders at the University of Pittsburgh. His research interests include the biology of acute inflammation in shock states, chronic inflammatory diseases, wound healing, malaria, and restenosis. His work utilizes mathematical modeling to unify and gain insight into the biological interactions that characterize these inflammatory conditions. As the Director of the Center for Inflammation and Regenerative Modeling (CIRM) at the University of Pittsburgh’s McGowan Institute for Regenerative Medicine, he has been involved in the mathematical modeling of acute inflammatory states (e.g. septic or hemorrhagic shock, wound healing), including cellular and physiological elements, as part of a large, interdisciplinary collaborative team. He is also a co-founder of Immunetrics, Inc., a company that is commercializing this mathematical modeling work. He is currently the President of the Society for Complexity in Acute Illness.

Lab Affiliation

Lab Role

PI

Publications

Chow, C. C.; Clermont, G.; Kumar, R.; Lagoa, C.; Tawadrous, Z.; Gallo, D.; Betten, B.; Bartels, J.; Constantine, G.; Fink, M. P.; Billiar, T. R.; Vodovotz, Y. The acute inflammatory response in diverse shock states. Shock  2005; 24:74-84.

Li, N.Y.K.; Verdolini, K.; Clermont, G.; Mi, Q.; Hebda, P.A.; Vodovotz, Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE. 2008. 3:e2789. PMC2481293

Vodovotz, Y., Csete, M.; Bartels, J.; Chang, S.; An, G. Translational systems biology of inflammation. PLoS Comput. Biol. 2008. 4:1-6. PMC2329781

Mi, Q.; Constantine, G.; Ziraldo, C.; Solovyev, A.; Torres, A.; Namas, R.; Bentley, T.; Billiar, T.R.; Zamora, R.; Puyana, J.C.; Vodovotz, Y. A dynamic view of trauma/hemorrhage-induced inflammation in mice: Principal drivers and networks. PLoS ONE. 2011. 2011.6:19424.

Nieman, G.; Brown, D.; Sarkar, J.; Kubiak, B.; Ziraldo, C.; Vieau, C.; Barclay, D.; Gatto, L.; Maier, K.; Zamora, R.; Mi, Q.; Chang, S.; Vodovotz, Y. Endotoxin-induced acute inflammation in swine: Insights from combined data-driven and mechanistic modeling. Crit. Care Med. 2012. 40:1052-1063. Crit. Care Med. Featured Article. Accompanying editorial: An, G. Small to large, lots to some, many to few: In silico navigation of the Translational Dilemma. Crit. Care Med. 2012. 40:1334-1335.

Namas R, Mikheev M, Yin J, Over P, Young M, Constantine G, Zamora R, Gerlach J, Vodovotz Y. A biohybrid device for the systemic control of acute inflammation. Disrupt. Science & Technol. 2012. 1:20-27.

Namas R, Namas R, Lagoa C, Barclay D, Mi Q, Zamora R, Peng Z, Wen X, Fedorchak M, Valenti IE, Federspiel W, Kellum JA, Vodovotz Y. Hemoadsorption reprograms inflammation in experiment Gram-negative septic fibrin peritonitis: Insights from in vivo and in silico studies. Mol. Med. 2012 (In Press).

An G, Bartels J, Vodovotz Y. In silico augmentation of the drug development pipeline: Examples from the study of acute inflammation. Drug Dev. Res. 2010. 72:1-14.

Namas R, Zamora R, Namas R, An G, Doyle J, Dick TE, Jacono FJ, Androulakis IP, Nieman GF, Chang S, Billiar TR, Angus DC, Vodovotz Y. Sepsis: Something old, something new, and a systems view. J. Crit. Care. 2012. 27:314 e1-314e11.

An G, Nieman G, Vodovotz Y. Computational and systems biology in trauma and sepsis: Current state and future perspectives. Int. J. Burns Trauma. 2012. 2:1-10.

Dick TE, Molkov YI, Nieman G, Hsieh Y-H, Jacono FJ, Doyle J, Scheff J, Calvano SE, Androulakis I, An G, Vodovotz Y. Linking inflammation, cardiorespiratory variability, and neural control in acute inflammation via computational modeling. Frontiers in Comp. Physiol. and Medicine. 2012. Vol. 3, article 222.

Zamora R, Azhar N, Namas R, Metukuri MR, Clermont T, Gladstone C, Namas R, Hermus L, Megas C, Contantine G, Billiar TR, Fink MP, Delude R, Vodovotz Y. Identification of a novel pathway of transforming growth factor-ß1 regulation by extracellular NAD+ in mouse macrophages: In vitro and in silico studies. J. Biol. Chem. 2012 287:31003-31014.