Rami Namas, MD
Research Assistant Professor
MBBCh, Al-Fatah University, School of Medicine, Tripoli, Libya
MRCS, GLasgow, Scotland
Post-Doctoral Fellow, Department of Surgery, University of Pittsburgh
My long-term research goals are to obtain high-dimensional, dynamic data on the etiology and progression of various inflammatory processes and diseases in samples derived from cells, animals, and humans; to create computational models based on these data; and to modulate the inflammatory response in an optimal spatial, temporal, and individual- / disease-specific manner. More specifically, my research interests, carried out in the context of an interdisciplinary research team, are the following:
1. Mechanisms regulating trauma-induced inflammation coupled with data-driven modeling to gain insights into the dynamics of the inflammatory response in human blunt trauma.
2. Novel class of biohybrid devices for regulating inflammation that target Tumor Necrosis Factor-α (TNF-α) through delivery of a protein antagonist (sTNFR) via genetically modified human hepatocytes.
3. Systems biology and mathematical modeling of inflammation and wound healing in various disease states, especially infection, trauma, and hemorrhage, and the application of these computational approaches to regenerative medicine and rational drug/device design.
4. In vivo and In vitro studies of LPS-induced endotoxemia in animal models and characterization of the role of hepatocytes and macrophages in the response to sepsis.
5. Effect of aging on the dynamics of systemic inflammation in the setting of trauma and sepsis in animal models and humans.
A biohybrid device for the systemic control of acute inflammation. Namas RA; Mikheev M; Yin J; Over P; Young M; Constantine G; Zamora R; Gerlach J; Vodovotz Y Disrupt.Science&Technol.2012.1:20-27.PMID:24205448
Hemoadsorption reprograms inflammation in experimental Gram-negative septic peritonitis: Insights from in vivo and in silico studies. Namas RA; Namas R; Lagoa C; Barclay D; Mi Q; Zamora R; Peng Z; Wen X; Fedorchak M; Valenti IE; Federspiel W; Kellum JA; Vodovotz Y Mol. Med. 2012. 18:1366-1374. Accompanying editorial: Honore, P.M.; Jacobs, R.; Joannes-Boyau, O.; Boer, W.; De Waele, E.; Van Gorp, V.; De Regt, J.; Spapen, H.D. Moving from a cytotoxic to a cytokinic approach in the blood purification labyrinth: Have we finally found Ariadne’s thread? Mol. Med. 2012. 18:1363-1365. PMID: 22751621
Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. Namas RA; Bartels J; Hoffman R; Barclay D; Billiar TR; Zamora R; Vodovotz Y. 2013. PLoS ONE. 8: e67419. PMID: 23844008
Inducible Protein-10, a Potential Driver of Neurally Controlled Interleukin-10 and Morbidity in Human Blunt Trauma. Zaaqoq AM; Namas RA; Almahmoud K; Azhar N; Mi Q; Zamora R; Brienza DM; Billiar TR; Vodovotz Y. Crit. Care Med. 2014 (Epub). PMID: 24584064
Sepsis: Something old, something new, and a systems view. Namas RA; Zamora R; Namas R; An G; Doyle J; Dick TE; Jacono FJ; Androulakis IP; Nieman GF; Chang S; Billiar TR, Angus DC; Vodovotz Y. J. Crit. Care. 2012. 27:314e1-314e11. PMID: 21798705