Patricia A. Loughran, PhD
S221 BST-South (CBI)
PhD in Biochemistry, University of Texas Health Science Center at San Antonio
Patricia Loughran studies protein subcellular localization and protein binding partners in models of inflammation, infection and hypoxia. These post- translational modifications are established means to alter protein structure and function that may potentially generate oxygen radicals that exacerbates the initial cellular insult. An additional area of interest is the sequence of events that may lead to protein modification and subsequent removal may involve damage-associated molecular pattern (DAMP) molecules. Autophagy and Apoptosis are both known to be triggered when cells have become damaged or nutrient deprived and exist as a controlled mechanism to minimize damage to the larger environment. To better understand the role of DAMP molecules in regulating balance between cell survival and cell death, Biochemistry, Cell Biology and cellular imaging are the primary tools utilized.
Loughran, P.A., Stolz, D.B., Barrick, S.R., Wheeler, D.S., Friedman, P.A., Watkins, S.C., Billiar, T.R. "PEX7 and EBP50 Target iNOS to the Peroxisome in Hepatocytes" Nitric Oxide: Biology and Chemistry In Press DOI:10.1016/j.niox.2013.02.084
Eum HA, Vallabhaneni R, Wang Y, Loughran PA, Stolz DB, Billiar TR. (2011) “Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-a-treated hepatocytes.” Am. J. Pathol. Sep; 179(3):1221-9.
Tang, D., Kang, R., Livesey, K.M. Cheh, C-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M.E., Tracey, K.J., Zeh, H.J. III, Lotze, M.T., (2010) “Endogenous HMGB1 Regulates Autophagy” J. Cell Biology. 190(5):881-892.
Tygai, P., Tygai, V., Yoshimura, N., Witteemer, E., Barclay, D., Loughran, P.A., Zamora, R., Vodovotz, Y. (2009) “Gender-based reciprocal expression of Transforming Growth Factor-β1 and the Inducible Nitric Oxide Synthase in a rat model of cyclophosphamide-induced cystitis” Journal of Inflammation. 6:23.
Kim, H.S. *, Loughran, P.A. *, Billiar, T.R., (2008) “Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes” Nitric Oxide. 18, 256-65.
Loughran, P.A., Stolz, D.B., Vodovotz, Y., Watkins, S.C. Simmons, R.L., Billiar, T.R. (2005) “Monomeric iNOS localizes to peroxisomes in hepatocytes” Proc. Natl. Acad. Sci. USA 102, 13837-13842.