Matthew R. Rosengart, M.D., MPH



headshot
412-647-0860
Fax: 412-647-1448

F1266.1 PUH

200 Lothrop Street

Pittsburgh, PA 15213

Associate Professor

Education

B.A. The Johns Hopkins University, Baltimore, MD

M.D. University of Alabama at Birmingham, Birmingham, AL

Residency University of Alabama at Birmingham, Birmingham, AL

Fellowship University of Washington, Seattle, WA

Residency University of Washington, Seattle, WA

MPH University of Washington, Seattle, WA

Fellowship University of Washington, Seattle, WA

Research Summary

Our laboratory has a long-standing record of examining the role of innate immunity in the systemic response to injury and infection, with particular expertise in calcium-dependent mechanisms. Dr. Rosengart’s laboratory has focused upon the mechanisms involved in the inflammatory processes that define the response to injury in relevant sepsis and trauma models such as LPS-induced inflammation and organ dysfunction, cecal ligation and puncture (CLP) polymicrobial sepsis, warm hepatic ischemia/reperfusion (I/R) injury, and hemorrhagic shock. By employing diverse strategies such as in vivo siRNA to generate genetically engineered mice lacking key components of the calcium-sensitive CaMK cascade, high-speed depth resolved optical mapping of calcium transients, electron and fluorescent microscopy of subcellular organelle and protein trafficking, and study of the ramifications of calcium supplementation on inflammation and organ dysfunction, Dr. Rosengart has contributed to the understanding of calcium-dependent regulation and signaling during the inflammatory states of sepsis and injury. The translational perspective of his studies has provided mechanistic insight into the ramifications of the common practice of calcium supplementation in critical illness on the clinically relevant outcomes of organ failure and survival.

Lab Affiliation

Lab Role

PI

Publications

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS. Hepatology. 2011 Jun;53(6):2053-62. doi: 10.1002/hep.24324. Epub 2011 May 2. | View Publication

Calcium/calmodulin-dependent protein kinase (CaMK) Ialpha mediates the macrophage inflammatory response to sepsis. Zhang X, Guo L, Collage RD, Stripay JL, Tsung A, Lee JS, Rosengart MR. J Leukoc Biol. 2011 Aug;90(2):249-61. Epub 2011 Mar 3. | View Publication

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway. Waltz P, Carchman EH, Young AC, Rao J, Rosengart MR, Kaczorowski D, Zuckerbraun BS. Autophagy. 2011 Mar;7(3):315-20. | View Publication

Parenteral calcium for intensive care unit patients. Forsythe RM, Wessel CB, Billiar TR, Angus DC, Rosengart MR. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006163. Review. | View Publication

Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. Zhang X, Wheeler D, Tang Y, Guo L, Shapiro RA, Ribar TJ, Means AR, Billiar TR, Angus DC, Rosengart MR. J Immunol. 2008 Oct 1;181(7):5015-23. | View Publication