Hai Huang

Fax: 412-624-1172

E1542 BST

Research Assistant Professor


B.M. Sun Yat-Sen University, Guangzhou, China

M.MedSc The University of Hong Kong, Hong Kong SAR, China

M.D. University of Duisburg-Essne, Faculty of Medicine Essen, Germany

Research Summary

Dr. Huang was accepted by Dr. Allan Tsung as a Post-doctoral Associate at the Starzl Transplantation Institute, University of Pittsburgh in November 2009. Because of his continued excellence in research endeavors, Dr. Huang was promoted to Research Instructor January 2014 and Research Assistant Professor in Department of Surgery, University of Pittsburgh since 2015. Since his arrival to the University of Pittsburgh, his research has been a significant contribution to efforts focused on identifying the mechanisms of ischemia-induced activation of inflammatory pathways and the pathogenesis of organ injury following liver ischemia reperfusion. Dr. Huang has been very productive with numerous first author papers in high impact journals, such as four in Hepatology and one inJournal of Immunology. Dr. Huang also received the 1st place Presidential Award at the Society for Leukocyte Biology Annual Meeting in 2014, 2015 Young Investigator Travel Award for the AASLD Liver Meeting as well as the 2012 Young Investigator Travel Award for the 7th Congress of the International Federation of Shock Societies.

Lab Affiliation


Huang H, Tohme S, Al-Khafaji AB, Tai S, Loughran P, Chen L, Wang S, Kim J, Billiar T, Wang Y, Tsung A. DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology. 2015 Apr 8. doi: 10.1002/hep.27841. [Epub ahead of print]

Huang H, Nace GW, McDonald KA, TaiS, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, Chang EB, Billiar T, Tsung A. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. Hepatology. 2013 Dec 21. doi: 10.1002/hep.26976. [Epub ahead of print]

Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M, Liao X, Billiar T, Xu J, Esmon CT, Tsung A. Endogenous histones function as alarmins in sterile inflammatory liver injury through toll-like receptor 9. Hepatology. 2011 Jun 30. doi: 10.1002/hep.24501.

Nace GW, Huang H (co-first author), Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology. 2013 Mar 4. doi: 10.1002/hep.26346. [Epub ahead of print]

Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW, Ding Q, Loughran P, Beer-Stolz D, Billiar TR, Esmon CT, Tsung A. Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury. J Immunol. 2013 Jul 31. [Epub ahead of print]