B.S. Cell & Molecular Biology, University of California Los Angeles, Ca
Ph.D. Toxicology, Dept of Environmental and Occupational Health, University of Pittsburgh
The main focus of the laboratory is to understand the role of the immune system in lung pathophysiologies, such as pulmonary hypertension. The presence of immune cells in patients’ pulmonary lesions points to a role of the immune system in this disease. We are especially interested in understanding the role of endogenous innate immune mediators (i.e.HMGB1), and receptors (Toll- like receptors), as well as the interplay of innate immune cells such as Natural Killer cells, Neutrophils, and Macrophages. Using a variety of rodent disease models coupled with genetically modified mice and cell culture models we explore the role of the immune system in the pathogenesis of this disease. We further aim to learn lessons from cancer immunotherapies by applying their mechanisms to our lung-pathophysiologies.
At a more basic scientific level we try to get an in depth understanding of HMGB1’s interaction with toll-like receptors, its nuclear role, its travel through the three dimensional cell, and the purpose of HMGB1’s newly identified binding partners by us and our colleagues in the department of surgery.
Another interest of the lab is to advance our understanding of the immune system in inflammatory lung pathologies by collaborating with Dr. Carolyn Anderson in the dept. of radiology to image immune cells in our in vivo models using Positron Emission Tomography.
Eileen M. Bauer, Chanthaphavong RS, Sodhi CP, Hackam DJ, Billiar TR, Philip M. Bauer. Genetic deletion of TLR4 on platelets attenuates experimental pulmonary hypertension. Circ Res. 2014 May 9;114(10):1596-600
P. Bernal, K Leelavanichkul, E Bauer, R Cao, A Wilson, K Wasserloos, S Watkins, B Pitt and C. St. Croix. Nitric oxide mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone. Circ Res. 102(12):1575-83. 2008
Eileen M. Bauer, Richard Shapiro, Han Zheng, Ferhaan Ahmad, David Ishizawar, Suzy A. Comhair, Serpil C. Erzurum, Timothy R. Billiar, and Philip M. Bauer. HMGB1 promotes experimental PH. Mol Med. 2013 Feb 8;18:1509-18.
Bauer PM, Bauer EM, Rogers NM, Yao M, Feijoo-Cuaresma M, Zuckerbraun BS, Calzada MJ, Isenberg JS. (2012) Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc. Res .2012.
Gambhir SS, Bauer E, Black ME, Liang Q, Kokoris MS, Barrio JR, Iyer M, Namavari M, Phelps ME, Herschman HR. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. PNAS U S A. 97(6):2785-90.2000