Edith Tzeng, M.D.



headshot
412-802-3025
Fax: 412-291-1669

A1011 PUH

200 Lothrop Street

Pittsburgh, PA 15213

Professor of Surgery, Division of Vascular Surgery

Education

Undergraduate – University of Illinois

Medical School – University of Chicago

Surgical Training – University of Pittsburgh

Research Summary

Dr. Tzeng’s research focuses on vascular related topics.  She has a strong focus on translational studies of vascular healing and wound healing.  The effect of small molecules such as carbon monoxide and nitric oxide on the prevention of intimal hyperplasia is an active area of research with an attempt to understand the mechanisms by which these molecules achieve their benefit in the vasculature.  Related to vascular healing is cutaneous wound healing.  The beneficial effects of CO and NO have also been shown in cutaneous wound healing and efforts are ongoing to better evaluate these effects.  The ultimate goal of her research is to bring these agents to clinical application.

Lab Affiliation

Lab Role

P.I.

Publications

Raman KG, Barbato JE, Ifedigbo E, Ozanich BS, Zenati MS, Otterbein LE, Tzeng E.  Inhaled carbon monoxide inhibits intimal hyperplasia and provides added benefit with nitric oxide.  J Vasc Surg.  2006; 44:151-158.

Raman KG, Gandley RE, Rohland J, Zenati MS, Tzeng E.  Early hypercholesterolemia contributes to vasomotor dysfunction and injury associated atherogenesis that can be inhibited by nitric oxide.  J Vasc Surg.  2011; 53:754-63.

Nakao A, Huang C-S, Stolz DB, Wang Y, Franks JM, Tochigi N, Billiar TR, Toyoda Y, Tzeng E, McCurry K.  Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts.  Cardiovasc Res.  2011; 98:457-64.

Alef MJ, Vallabhaneni R, Carchman E, Morris SM Jr, Shiva S, Wang Y, Kelley EE, Tarpey MM, Galdwin MT, Tzeng E, Zuckerbraun BS (co-senior author).  Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats.  J Clin Invest.  2011; 121:1646-56.

Sachdev U, Cui X, Hong G, Namkoong S, Karlsson JM, Baty CJ, Tzeng E.  High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury.  J Vasc Surg.  2012; 55:180-91.