Brian S. Zuckerbraun, M.D.
200 Lothrop Street
B.S. Northwestern University, College of Arts and Sciences
M.D. Northwestern University Medical School
The lab primarily investigates the acute inflammatory response in the liver and vasculature following injury from trauma/hemorrhagic shock, sepsis, or direct vascular injury. Much of the work has focused on the role of gaseous signaling molecules, including nitric oxide and carbon monoxide. Specifically, we have been investigating the induction of adaptive signaling pathways and how these molecules regulate mitochondrial responses to these stresses to influence immunity and inflammation.
Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS. Hepatology. 2011 Jun;53(6):2053-62. doi: 10.1002/hep.24324. Epub 2011 May 2. PMID: 21437926 [PubMed - indexed for MEDLINE]
Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats. Alef MJ, Vallabhaneni R, Carchman E, Morris SM Jr, Shiva S, Wang Y, Kelley EE, Tarpey MM, Gladwin MT, Tzeng E, Zuckerbraun BS. J Clin Invest. 2011 Apr;121(4):1646-56. doi: 10.1172/JCI44079. Epub 2011 Mar 23. PMID: 21436585 [PubMed - indexed for MEDLINE]
Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway. Waltz P, Carchman EH, Young AC, Rao J, Rosengart MR, Kaczorowski D, Zuckerbraun BS. Autophagy. 2011 Mar;7(3):315-20. PMID: 21307647 [PubMed - indexed for MEDLINE]
Carbon monoxide reverses established pulmonary hypertension. Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE. J Exp Med. 2006 Sep 4;203(9):2109-19. Epub 2006 Aug 14. PMID: 16908624 [PubMed - indexed for MEDLINE]
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AM, Bach FH, Otterbein LE. J Exp Med. 2003 Dec 1;198(11):1707-16.